2014-09-24 New derivatives of Imidazo[1,2-b]pyrazoles on Ambinter

In order to provide new and original chemical compounds to our customers, Greenpharma/Ambinter has developed innovative synthesis routes with partners. For example, C-2/C-6/C-7 trisubstituted, C-2/C-3/C-6 tri(hetero)arylated and C-2/C-3/C-6/C-7 tetrasubstituted imidazo[1,2-b]pyrazoles of imidazo[1,2-b]pyrazoles are now available in Ambinter catalogue.

You can find more information on the publication (abstract below) in European Journal of Medicinal Chemistry, 2014, 84, 718-730.

New imidazo[1,2-b]pyrazoles as anticancer agents: Synthesis, biological evaluation and structure activity relationship analysis

Synthesis and functionalization strategies of the imidazo[1,2-b]pyrazole core were developed giving a rapid access to three series of novel imidazo[1,2-b]pyrazole type derivatives: C-2/C-6/C-7 trisubstituted, C-2/C-3/C-6 tri(hetero)arylated and C-2/C-3/C-6/C-7 tetrasubstituted imidazo[1,2-b]pyrazoles. 39 of the synthetized products were evaluated for in vitro anticancer activity using the MTT colorimetric assay against 5 human and 1 murine cancer cell lines. Promising in vitro growth inhibitory activities were exhibited by some of the target compounds.
Of the 39 evaluated products, 4 displayed an IC50 10 mM in the 6 cell lines analyzed.

Click on the link to display the structures of imidazo[1,2-b]pyrazoles library.